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Pharmacology: The mode of action of Azithromycin is inhibition of protein synthesis in bacteria by binding to the 50s ribosomal subunit and preventing translocation of peptides.
Pharmacokinetics: Absorption: Bioavailability - 37%; Effects of food - reduces bioavailability about 50%.
Distribution: Widely distributed throughout the body; Heavily tissue-bound (up to 50 times the maximum concentration observed in plasma).
Time to peak plasma concentration: 2-3 hours.
Excretion: Biliary - Very high concentration of unchanged drug found; Renal.
Plasma terminal elimination half-life: 2-4 days.
